Kirilenko then lost four matches in a row at Dubai, Bangalore, Indian Wells, and Miami.
She won the 2002 US Open Girls' Singles, and won her first title on the WTA Tour in 2005, defeating Anna-Lena Grönefeld in the China Open.She also won the doubles title there, partnering with Flavia Pennetta.Kirilenko also won in Barcelona, defeating Martinez-Sanchez for her fourth career WTA title and the second of the year.They made it to the third round, before losing to 11th seeded Anna-Lena Grönefeld of Germany and Patty Schnyder of Switzerland.Kirilenko was unseeded at Wimbledon and made it to the second round, losing to ninth seeded Caroline Wozniacki.She reached three Grand Slam singles quarterfinals, at the 2010 Australian Open, the 2012 Wimbledon Championships, and the 2013 French Open.
In women's doubles, she reached two Grand Slam finals, at the 2011 Australian Open and the 2012 French Open, won the 2012 WTA Tour Championships and was a bronze medalist at the 2012 London Olympics.
In the Dubai doubles tournament, Kirilenko partnered with Agnieszka Radwańska, and even though they were unseeded, they reached the final, eventually losing to Liezel Huber and Cara Black, the world No. At the 2009 French Open, Kirilenko was unseeded in the singles tournament, and lost to Olivia Rogowska of Australia in the first round.
In the doubles tournament, Kirilenko and doubles partner Flavia Pennetta of Italy were seeded eighth.
In June 2013, Kirilenko reached her career-high ranking of world No. In September 2014, she played her last WTA event in Beijing.
In 2002, Kirilenko became one of the youngest winners of the junior tournaments at the Canadian Open and US Open.
At the Acura Classic in San Diego, California, Kirilenko upset second seeded Jelena Janković to advance to the quarterfinals, before losing to fellow Russian Elena Dementieva.